pitanje

nisam znao, ali pronašao u literaturi, u pubmed bazi podataka. Psihogena febrilnost se opisuje ponajviše u Japanu i deluje dosta bezazleno;  leči se anksioloiticima, a antipiretici ne pomažu, evo pročitajte i vi siže tog revijalnog teksta. Drugi autori smatraju da je uvek neophodno isključiti neke inflamatorne bolesti, koje se mogu kriti iza "psyhognic fever"

Temperature 2:3, 368--378; July/August/September 2015; Published with license by Taylor & Francis Group, LLC

Takakazu Oka*
Department of Psychosomatic Medicine; Graduate School of Medical Sciences; Kyushu University; Fukuoka, Japan

Psychogenic fever:
how psychological stress affects body
temperature in the clinical population

Psychogenic fever is a stress-related, psychosomatic disease especially seen in young women. Some patients
develop extremely high core body temperature (Tc) (up to 41C) when they are exposed to emotional events, whereas
others show persistent low-grade high Tc (37–38C) during situations of chronic stress. The mechanism for psychogenic
fever is not yet fully understood. However, clinical case reports demonstrate that psychogenic fever is not attenuated
by antipyretic drugs, but by psychotropic drugs that display anxiolytic and sedative properties, or by resolving patients’
difficulties via natural means or psychotherapy. Animal studies have demonstrated that psychological stress increases
Tc via mechanisms distinct from infectious fever (which requires proinflammatory mediators) and that the sympathetic
nervous system, particularly b3-adrenoceptor-mediated non-shivering thermogenesis in brown adipose tissue, plays an
important role in the development of psychological stress-induced hyperthermia. Acute psychological stress induces a

transient, monophasic increase in Tc. In contrast, repeated stress induces anticipatory hyperthermia, reduces diurnal
changes in Tc, or slightly increases Tc throughout the day. Chronically stressed animals also display an enhanced
hyperthermic response to a novel stress, while past fearful experiences induce conditioned hyperthermia to the fear

context. The high Tc that psychogenic fever patients develop may be a complex of these diverse kinds of hyperthermic

responses.

ima i ovo

Psychogenic fever reflects a phenomenon where core body temperature is high (up to 41°C) or low-grade high (37–38°C) during either acute or chronic stress. Underlying mechanisms are distinct from infection-induced fever and involve the central and sympathetic nervous systems. Psychogenic fever appears a complex psychological, physiological and endocrinological phenomenon.